MicroRNA-regulated feed forward loop network
نویسندگان
چکیده
منابع مشابه
Structure and function of the feed-forward loop network motif.
Engineered systems are often built of recurring circuit modules that carry out key functions. Transcription networks that regulate the responses of living cells were recently found to obey similar principles: they contain several biochemical wiring patterns, termed network motifs, which recur throughout the network. One of these motifs is the feed-forward loop (FFL). The FFL, a three-gene patte...
متن کاملFeed forward neural network entities
Feed Forward Neural Networks (FFNNs) are computational techniques inspired by the physiology of the brain and used in the approximation of general mappings from one nite dimensional space to another. They present a practical application of the theoretical resolution of Hilbert's 13 th problem by Kolmogorov and Lorenz, and have been used with success in a variety of applications. However, as the...
متن کاملSignal Prediction by Layered Feed - Forward Neural Network (RESEARCH NOTE).
In this paper a nonparametric neural network (NN) technique for prediction of future values of a signal based on its past history is presented. This approach bypasses modeling, identification, and parameter estimation phases that are required by conventional parametric techniques. A multi-layer feed forward NN is employed. It develops an internal model of the signal through a training operation...
متن کاملNoise processing by microRNA-mediated circuits: The Incoherent Feed-Forward Loop, revisited
The intrinsic stochasticity of gene expression is usually mitigated in higher eukaryotes by post-transcriptional regulation channels that stabilise the output layer, most notably protein levels. The discovery of small non-coding RNAs (miRNAs) in specific motifs of the genetic regulatory network has led to identifying noise buffering as the possible key function they exert in regulation. Recent ...
متن کاملPHA-4/FOXA-regulated microRNA feed forward loops during Caenorhabditis elegans dietary restriction
Dietary restriction (DR) increases life span and delays the onset of age-related diseases across species. However, the molecular mechanisms have remained relatively unexplored in terms of gene regulation. InC. elegans, a popular model for aging studies, the FOXA transcription factor PHA-4 is a robust genetic regulator of DR, although little is known about how it regulates gene expression. We pr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Cycle
سال: 2009
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.8.16.9271